(19)

(11)

EP 2 188 281 A1

(12)

(43) Date of publication: 26.05.2010 Bulletin 2010/21 (21) Application number: 08795247.9 (22) Date of filing: 11.08.2008

(51) International Patent Classification (IPC):  C07D 407/12(2006.01) A61K 31/70(2006.01) C07H 17/08(2006.01) A61P 31/08(2006.01) (86) International application number: PCT/US2008/009642 (87) International publication number: WO 2009/023196 (19.02.2009 Gazette 2009/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 10.08.2007 US 964296 P (71) Applicants: Y's Therapeutics Co, Ltd. Tokyo 150-0021 (JP) The University of Tokyo Tokyo 113-8654 (JP)	(72) Inventors: MORIMOTO, Chikao Tokyo 156-0043 (JP) CHEUNG, Peter, H. The Woodlands, TX 77385 (US) TSUZUKI, Kazuo Tsukuba-shi Ibaraki 305-0861 (JP) (74) Representative: Woods, Geoffrey Corlett  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ Gray's Inn London WC1R 5JJ (GB)