(19)

(11)

EP 2 190 427 A1

(12)

(43) Date of publication: 02.06.2010 Bulletin 2010/22 (21) Application number: 08804825.1 (22) Date of filing: 26.09.2008

(51) International Patent Classification (IPC):  A61K 31/355(2006.01) A61P 29/00(2006.01) A61P 25/28(2006.01) A61K 31/353(2006.01) (86) International application number: PCT/EP2008/062953 (87) International publication number: WO 2009/040423 (02.04.2009 Gazette 2009/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 26.09.2007 EP 07301397 (71) Applicant: INSERM (Institut National de la Santé et de la Recherche Médicale) 75654 Paris Cedex 13 (FR)	(72) Inventors: BARON-VAN EVERCOOREN, Anne F-75005 Paris (FR) NAIT OUMESMAR, Brahim F-75013 Paris (FR) (74) Representative: Cabinet Plasseraud  52, rue de la Victoire 75440 Paris Cedex 09 75440 Paris Cedex 09 (FR)