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(11)

EP 2 192 918 A1

(12)

(43) Date of publication: 09.06.2010 Bulletin 2010/23 (21) Application number: 08798605.5 (22) Date of filing: 25.08.2008

(51) International Patent Classification (IPC):  A61K 39/21(2006.01) C07K 14/16(2006.01) (86) International application number: PCT/US2008/074179 (87) International publication number: WO 2009/029569 (05.03.2009 Gazette 2009/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 24.08.2007 US 966048 P (71) Applicant: Novartis AG 4056 Basel (CH)	(72) Inventors: BARNETT, Susan W. Emeryville, California 94662-8907 (US) LIAN, Ying Emeryville, California 94662-8907 (US) SHARMA, Victoria Emeryville, California 94662-8907 (US) SRIVASTAVA, Indresh K. Emeryville, California 94662-8907 (US) (74) Representative: Marshall, Cameron John  Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)