(19)

(11)

EP 2 194 975 A2

(12)

(88) Date of publication A3: 26.03.2009 (43) Date of publication: 16.06.2010 Bulletin 2010/24 (21) Application number: 08826259.7 (22) Date of filing: 11.07.2008

(51) International Patent Classification (IPC):  A61K 31/15(2006.01) A61P 9/10(2006.01) A61P 25/28(2006.01) (86) International application number: PCT/US2008/069878 (87) International publication number: WO 2009/009768 (15.01.2009 Gazette 2009/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 12.07.2007 US 777264 12.07.2007 US 777266 19.07.2007 US 950724 P 19.07.2007 US 950810 P (71) Applicant: Acumen Pharmaceuticals, Inc. Livermore, CA 94551 (US)

(72) Inventors: LOOK, Gary Charles Santa Clara, California 95051 (US) SCHULTZ, Lauri Batavia, Illinois 60510 (US) POLOZOV, Alexandre Mikhaylovich Naperville, Illinois 60565 (US) BHAGAT, Nikhil Aurora, Illinois 60503-5762 (US) WANG, Jian San Diego, California 92129 (US) ZEMBOWER, David E. La Grange, Illinois 60525 (US) GOURE, William, F. Livermore, California 94551 (US) PRAY, Todd San Mateo, California 94554 (US) KRAFFT, Grant, A. Glenview, Illinois 60025 (US) (74) Representative: Wibbelmann, Jobst  Wuesthoff & Wuesthoff Patent- und Rechtsanwälte Schweigerstrasse 2 81541 München 81541 München (DE)