(19)

(11)

EP 2 195 036 A1

(12)

(43) Date of publication: 16.06.2010 Bulletin 2010/24 (21) Application number: 08725637.6 (22) Date of filing: 15.02.2008

(51) International Patent Classification (IPC):  A61K 51/02(2006.01) A61M 36/06(2006.01) (86) International application number: PCT/US2008/002026 (87) International publication number: WO 2009/045230 (09.04.2009 Gazette 2009/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 05.10.2007 US 997873 P 05.10.2007 US 997856 P (71) Applicants: ISO Therapeutics Group LLC Angleton TX 77515 (US) Gabriel Institute, INC. 1502 Augusta Drive, Suite 390 Houston, TX 77057-2515 (US)	(72) Inventors: FRANK, R., Keith Lake Jackson TX 77566 (US) MCMILLAN, Kenneth Richwood TX 77531 (US) SIMON, Jaime Angleton TX 77515 (US) LOY, H., Max Houston TX 77055 (US) STEARNS, Stanley, D. Houston TX 77055 (US) (74) Representative: Raynor, John  Beck Greener Fulwood House 12 Fulwood Place London WC1V 6HR London WC1V 6HR (GB)