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EP 2 195 447 A1

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(43) Date of publication: 16.06.2010 Bulletin 2010/24 (21) Application number: 08800381.9 (22) Date of filing: 26.09.2008

(51) International Patent Classification (IPC):  C12Q 1/48(2006.01) C07H 19/20(2006.01) C12Q 1/00(2006.01) G01N 27/403(2006.01) C07H 19/10(2006.01) C07K 16/44(2006.01) C40B 30/08(2006.01) (86) International application number: PCT/CA2008/001690 (87) International publication number: WO 2009/039639 (02.04.2009 Gazette 2009/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 27.09.2007 US 960388 P (71) Applicants: Kraatz, Heinz-Bernhard London, Ontario N5Z 4S5 (CA) Kerman, Kagan Toronto, M1H 3J2, ON (CA) Song, Haifeng London, Ontario N5X 4L2 (CA)	(72) Inventors: Kraatz, Heinz-Bernhard London, Ontario N5Z 4S5 (CA) Kerman, Kagan Toronto, M1H 3J2, ON (CA) Song, Haifeng London, Ontario N5X 4L2 (CA) (74) Representative: Crooks, Elizabeth Caroline  Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)