(19)

(11)

EP 2 197 433 A2

(12)

(88) Date of publication A3: 16.04.2009 (43) Date of publication: 23.06.2010 Bulletin 2010/25 (21) Application number: 08798295.5 (22) Date of filing: 20.08.2008

(51) International Patent Classification (IPC):  A61K 31/015(2006.01) A61K 38/00(2006.01) (86) International application number: PCT/US2008/073756 (87) International publication number: WO 2009/026389 (26.02.2009 Gazette 2009/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 20.08.2007 US 965463 P (71) Applicant: MOUNT SINAI SCHOOL OF MEDICINE New York, NY 10029 (US)	(72) Inventors: MARGOLSKEE, Robert, F. Upper Montelair, NJ 07043 (US) SHIRAZI-BEECHEY, Soraya Liverpool L69 7ZJ (GB) EGAN, Josephine Baltimore, MD 21209 (US) (74) Representative: Adamson Jones  BioCity Nottingham Pennyfoot Street Nottingham Nottinghamshire NG1 1GF Nottingham Nottinghamshire NG1 1GF (GB)