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(11)

EP 2 197 494 A2

(12)

(88) Date of publication A3: 03.09.2009 (43) Date of publication: 23.06.2010 Bulletin 2010/25 (21) Application number: 08801881.7 (22) Date of filing: 05.09.2008

(51) International Patent Classification (IPC):  A61K 47/48(2006.01) A61P 17/06(2006.01) A61P 19/02(2006.01) A61P 37/00(2006.01) A61P 29/00(2006.01) A61P 11/06(2006.01) A61P 37/06(2006.01) (86) International application number: PCT/EP2008/007288 (87) International publication number: WO 2009/030492 (12.03.2009 Gazette 2009/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 05.09.2007 EP 07017412 (71) Applicants: Freie Universität Berlin 14195 Berlin (DE) Charité - Universitätsmedizin Berlin 10117 Berlin (DE)	(72) Inventors: REISSIG, Hans-Ulrich 12165 Berlin (DE) DERNEDDE, Jens 10629 Berlin (DE) SCHLECHT, Sabine 10963 Berlin (DE) ROSKAMP, Meike 10717 Berlin (DE) ENDERS, Sven 10589 Berlin (DE) YEKTA, Shahla Vancouver British Columbia V6K 2P6 (CA) (74) Representative: Engelhard, Markus  Forrester & Boehmert Pettenkoferstrasse 20-22 D-80336 München D-80336 München (DE)