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(11)

EP 2 197 916 A1

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(43) Date of publication: 23.06.2010 Bulletin 2010/25 (21) Application number: 08804245.2 (22) Date of filing: 16.09.2008

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 19/02(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/EP2008/062286 (87) International publication number: WO 2009/040268 (02.04.2009 Gazette 2009/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 24.09.2007 GB 0718684 24.09.2007 US 974641 P (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventor: CLOSE, David Robert Shire Park Hertfordshire AL7 1TW (GB) (74) Representative: Heiroth, Ulrike Hildegard  F. Hoffmann-La Roche AG Patent Department 4070 Basel 4070 Basel (CH)