(19)

(11)

EP 2 203 432 A1

(12)

(43) Date of publication: 07.07.2010 Bulletin 2010/27 (21) Application number: 08831660.9 (22) Date of filing: 16.09.2008

(51) International Patent Classification (IPC):  C07D 241/04(2006.01) A61K 31/18(2006.01) A61K 31/17(2006.01) (86) International application number: PCT/US2008/076519 (87) International publication number: WO 2009/039091 (26.03.2009 Gazette 2009/13)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 21.09.2007 US 974175 P (71) Applicant: GlaxoSmithKline LLC Philadelphia, PA 19102 (US)	(72) Inventors: LEONARD, Thomas, B. Wayne PA 19087 (US) SARAU, Henry, M. Harleysville PA 19438 (US) LAZAAR, Aili, L. King Of Prussia PA 19406 (US) (74) Representative: Le Mière, Jennifer Louise  GlaxoSmithKline Services Unlimited Corporate Intellectual Property 980 Great West Road GB-Bentford, Middlesex TW8 9GS GB-Bentford, Middlesex TW8 9GS (GB)