(19)

(11)

EP 2 205 234 A2

(12)

(88) Date of publication A3: 14.05.2009 (43) Date of publication: 14.07.2010 Bulletin 2010/28 (21) Application number: 08834564.0 (22) Date of filing: 16.09.2008

(51) International Patent Classification (IPC):  A61K 31/167(2006.01) A61K 31/203(2006.01) A61K 31/21(2006.01) A61P 27/02(2006.01) (86) International application number: PCT/US2008/076499 (87) International publication number: WO 2009/042444 (02.04.2009 Gazette 2009/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 27.09.2007 US 975765 P 19.10.2007 US 981322 P (71) Applicant: Sirion Therapeutics, Inc. San Diego, CA 92121 (US)	(72) Inventors: MATA, Nathan, L. San Diego CA 92130 (US) PHAN, Kim, B. San Diego CA 92127 (US) BUI, Tam, V. Laguna Niguel CA 92677 (US) HADDACH, Mustapha San Diego CA 92127 (US) (74) Representative: Cole, William Gwyn et al HLBBshaw Merlin House Falconry Court Baker's Lane GB-Epping, Essex CM16 5DQ GB-Epping, Essex CM16 5DQ (GB)