(19)

(11)

EP 2 209 482 A2

(12)

(43) Date of publication: 28.07.2010 Bulletin 2010/30 (21) Application number: 08836519.2 (22) Date of filing: 03.10.2008

(51) International Patent Classification (IPC):  A61K 35/34(2006.01) C12N 5/08(0000.00) A61K 35/12(2006.01) (86) International application number: PCT/US2008/011458 (87) International publication number: WO 2009/045506 (09.04.2009 Gazette 2009/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 04.10.2007 US 977450 P (71) Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education Pittsburgh, PA 15260 (US)	(72) Inventors: PAYNE, Thomas Pittsburgh PA 15232 (US) PRUCHNIC, Ryan Pittsburgh PA 15215 (US) JANKOWSKI, Ronald Pittsburgh, PA (US) (74) Representative: Clarke, Victoria et al Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP Alder Castle 10 Noble Street London EC2V 7JX London EC2V 7JX (GB)