| (19) |
 |
|
(11) |
EP 2 210 888 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
15.09.2010 Bulletin 2010/37 |
| (43) |
Date of publication A2: |
|
28.07.2010 Bulletin 2010/30 |
| (22) |
Date of filing: 10.05.2006 |
|
| (51) |
International Patent Classification (IPC):
|
|
| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE
SI SK TR |
| (30) |
Priority: |
10.05.2005 US 679952 P
11.05.2005 US 680115 P
24.05.2005 US 684455 P
10.08.2005 US 707417 P
19.08.2005 US 709954 P
13.09.2005 US 716995 P
29.09.2005 US 722388 P
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
06759583.5 / 1763525 |
| (71) |
Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
|
49131 Petah Tiqva (IL) |
|
| (72) |
Inventors: |
|
- Kurgan, Ziv
Beer-sheva (IL)
- Pesachovich, Michael
Givat-shmuel (IL)
|
| (74) |
Representative: Lumsden, Stuart Edward Henry |
|
D Young & Co LLP
120 Holborn
London EC1N 2DY
London EC1N 2DY (GB) |
|
| |
|
| (54) |
Stable micronized candesartan cilexetil and methods for preparing thereof |
(57) The invention encompasses stable candesartan cilexetil of fine particle size, wherein
desethyl-candesartan (desethyl-CNS) within the stable candesartan cilexetil does not
increase to more than about 0.1%w/w by HPLC relative to the initial amount of candesartan
cilexetil, when the stable candesartan cilexetil is maintained at a temperature of
about 55°C for at least 2 weeks, methods of making the same and pharmaceutical compositions
thereof.