(19)
(11) EP 2 210 971 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
27.10.2010 Bulletin 2010/43

(43) Date of publication:
28.07.2010 Bulletin 2010/30

(21) Application number: 09425018.0

(22) Date of filing: 26.01.2009
(51) International Patent Classification (IPC): 
D04B 1/22(2006.01)
 A61L 27/18(2006.01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA RS

(71) Applicants:
  • Politecnico di Milano
    20133 Milano (IT)
  • Stazione Sperimentale per la Seta
    20133 Milano (IT)

(72) Inventors:
  • Freddi, Giuliano
    20133 Milano (IT)
  • Tanzi, Maria Cristina
    20133 Milano (IT)
  • Fare' , Silvia
    20133 Milano (IT)
  • Alessandrino, Antonio
    20133 Milano (IT)
  • Calimani, Roberto
    20129 Milano (IT)

(74) Representative: Long, Giorgio et al
Jacobacci & Partners S.p.A. Via Senato 8
20121 Milano
20121 Milano (IT)

   


(54) Silk fibroin textile structures as biomimetic prosthetics for the regeneration of tissues and ligaments


(57) The invention concerns a silk fibroin weave structure comprising a concentric tubular outer sheath and an inner core, wherein said sheath is a woven fabric with interlaced loop and said core is a woven fabric with interlaced loop or is braided using a braiding machine.
The silk fibroin used to weave the structure of the invention is a silk yarn with a linear density comprised of between approx. 40 den and approx. 640 den, preferably, the linear density is approx. 80 den or approx. 320 den.
The core of the structure has a mean pore area comprised of between 0.001 and 2.000 mm2, while the outer sheath has a mean pore area comprised of between 0.005 and 15.000 mm2.
The structure of the invention is used for the in vivo or in vitro regeneration of ligaments, particularly the anterior cruciate ligament, tendons, muscles and blood vessels. Furthermore, the structure promotes in vivo and in vitro cell adhesion and proliferation.