(19)

(11)

EP 2 212 694 A2

(12)

(88) Date of publication A3: 20.08.2009 (43) Date of publication: 04.08.2010 Bulletin 2010/31 (21) Application number: 08847388.9 (22) Date of filing: 06.11.2008

(51) International Patent Classification (IPC):  G01N 33/48(2006.01) G01N 31/20(2006.01) G01N 33/15(2006.01) G01N 31/22(2006.01) (86) International application number: PCT/US2008/082660 (87) International publication number: WO 2009/061935 (14.05.2009 Gazette 2009/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 06.11.2007 US 985924 P 06.11.2007 US 985922 P (71) Applicant: Emory University Atlanta, GA 30322 (US)	(72) Inventors: DINGLEDINE, Raymond, J. Atlanta GA 30345 (US) TRAYNELIS, Stephen, F. Decatur GA 30033 (US) LIOTTA, Dennis, C. Atlanta GA 30345 (US) (74) Representative: Hallybone, Huw George  Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)