(19)

(11)

EP 2 214 697 A2

(12)

(88) Date of publication A3: 24.09.2009 (43) Date of publication: 11.08.2010 Bulletin 2010/32 (21) Application number: 08844676.0 (22) Date of filing: 24.10.2008

(51) International Patent Classification (IPC):  A61K 38/16(2006.01) A61P 19/10(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2008/081168 (87) International publication number: WO 2009/058690 (07.05.2009 Gazette 2009/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 30.10.2007 US 983903 P (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: TING, Kang Beverly Hills, CA 90211 (US) SOO, Chia Beverly Hills, CA 90211 (US) ZHANG, Xinli Los Angeles, CA 90034 (US) (74) Representative: De Anna, Pier Luigi et al Notarbartolo & Gervasi GmbH Bavariaring 21 80336 München 80336 München (DE)