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EP 2 215 074 A1

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(43) Date of publication: 11.08.2010 Bulletin 2010/32 (21) Application number: 08833236.6 (22) Date of filing: 26.09.2008

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 405/04(2006.01) A61K 31/4035(2006.01) C07D 403/04(2006.01) C07D 409/04(2006.01) A61P 21/00(2006.01) (86) International application number: PCT/US2008/077936 (87) International publication number: WO 2009/042907 (02.04.2009 Gazette 2009/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 27.09.2007 US 975675 P (71) Applicants: The United States of America, as Represented by the Secretary, Department of Health and Human Services National Institutes of Health Office of Technology Transfer MSC 7660 Bethesda, Maryland 20892-7660 (US) Science Applications International Corporation (SAIC) 10260 Campus Point Drive San Diego, California 92121 (US) Albany Molecular Research, INC. 21 Corporate Circle P.O. Box 15098 Albany, New York 12212 (US)

(72) Inventors: HEEMSKERK, Jill E. Bethesda Maryland 20814 (US) MCCALL, John M. Boca Grande Florida 33921 (US) BARNES, Keith D. Rexford New York 12148 (US) (74) Representative: Pfenning, Meinig & Partner GbR  Patent- und Rechtsanwälte Theresienhöhe 13 80339 München 80339 München (DE)