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EP 2 217 592 A1

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(43) Date of publication: 18.08.2010 Bulletin 2010/33 (21) Application number: 08844595.2 (22) Date of filing: 29.10.2008

(51) International Patent Classification (IPC):  C07D 403/10(2006.01) C07D 413/10(2006.01) A61K 31/4025(2006.01) A61P 37/08(2006.01) C07D 405/10(2006.01) A61K 31/422(2006.01) A61K 31/5355(2006.01) (86) International application number: PCT/US2008/012272 (87) International publication number: WO 2009/058300 (07.05.2009 Gazette 2009/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 30.10.2007 US 1017 08.08.2008 US 188420 (71) Applicant: Arena Pharmaceuticals, Inc. San Diego, CA 92121-3223 (US)

(72) Inventors: SANTORA, Vincent J. Carlsbad California 92008 (US) COVEL, Jonathan A. San Diego California 92129 (US) ESTRADA, Scott A. La Jolla California 92037 (US) IBARRA, Jason B. Las Vegas Nevada 89139 (US) REN, Albert S. San Diego California 92130 (US) SCHULTZ, Jeffrey A. San Diego California 92130 (US) SEMPLE, Graeme San Diego California 92127 (US) SMITH, Brian M. San Diego California 92129 (US) SMITH, Jeffrey San Diego California 92131 (US) WEINHOUSE, Michael I. Escondido California 92029 (US) (74) Representative: Wytenburg, Wilhelmus Johannes et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)