(19)

(11)

EP 2 219 600 A1

(12)

(43) Date of publication: 25.08.2010 Bulletin 2010/34 (21) Application number: 07867501.4 (22) Date of filing: 19.11.2007

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 9/08(2006.01) A61K 8/19(2006.01) A61K 8/97(2006.01) A61K 9/06(2006.01) A61K 8/02(2006.01) A61K 8/67(2006.01) (86) International application number: PCT/US2007/024109 (87) International publication number: WO 2009/067095 (28.05.2009 Gazette 2009/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (71) Applicant: STIEFEL LABORATORIES, INC. Coral Gables, FL 33134 (US)	(72) Inventors: CAETANO, Joao, Paulo CEP 11050 070 Boqueirao-santos - Sao Paulo (BR) DE OLIVEIRA, Monica Alves, Mariani CEP 07400-000 Nova Aruja-Aruja-SP (BR) (74) Representative: Reeves, Julie Frances  GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road GB-Brentford, Middlesex TW8 9GS GB-Brentford, Middlesex TW8 9GS (GB)