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(11)

EP 2 220 065 A2

(12)

(88) Date of publication A3: 23.04.2009 (43) Date of publication: 25.08.2010 Bulletin 2010/34 (21) Application number: 08794832.9 (22) Date of filing: 28.07.2008

(51) International Patent Classification (IPC):  C07D 333/40(2006.01) C07D 409/12(2006.01) A61K 31/381(2006.01) C07D 333/70(2006.01) C07D 495/04(2006.01) (86) International application number: PCT/US2008/009142 (87) International publication number: WO 2009/017719 (05.02.2009 Gazette 2009/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 30.07.2007 US 962640 P (71) Applicant: ENCYSIVE PHARMACEUTICALS, INC. New York, NY 10017-5755 (US)

(72) Inventors: ANDERSON, Eric, C. Houston, TX 77005 (US) BIEDIGER, Ronald, J. Houston, TX 77042 (US) CHEN, Jie Houston, TX 77036 (US) DUPRE, Brian Houston, TX 77042 (US) LORY, Pedro 2018 Antwerp (BE) MARKET, Robert, V. Pearland, TX 77584 (US) MONK, Keith, A. League City, TX 77573 (US) SAVAGE, Michael, M. Pearland, TX 77581 (US) TENNYSON, Reginald Missouri City, TX 77459 (US) YOUNG, Brandon, M. Germantown, TN 38138 (US) (74) Representative: Laurent, Claire et al Pfizer Limited European Patent Department Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)