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(11)

EP 2 220 097 A1

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(43) Date of publication: 25.08.2010 Bulletin 2010/34 (21) Application number: 08848689.9 (22) Date of filing: 13.11.2008

(51) International Patent Classification (IPC):  C07F 5/02(2006.01) A61K 31/69(2006.01) (86) International application number: PCT/US2008/012706 (87) International publication number: WO 2009/064414 (22.05.2009 Gazette 2009/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 13.11.2007 US 2797 (71) Applicant: Protez Pharmaceuticals, Inc. Malvern, PA 19355 (US)	(72) Inventors: BURNS, Christopher J. Malvern Pennsylvania 19355 (US) JACKSON, Randy W. Glenmoore Pennsylvania 19343 (US) GOSWAMI, Rajesh Upper Darby Pennsylvania 19082 (US) XU, Hongyu Phoenixville Pennsylvania 19460 (US) (74) Representative: von Sprecher, Georg  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)