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EP 2 222 638 A2

(12)

(88) Date of publication A3: 30.07.2009 (43) Date of publication: 01.09.2010 Bulletin 2010/35 (21) Application number: 08851045.8 (22) Date of filing: 20.11.2008

(51) International Patent Classification (IPC):  C07D 207/16(2006.01) C07D 213/79(2006.01) C07D 239/42(2006.01) C07D 471/04(2006.01) C07D 473/40(2006.01) C07D 213/06(2006.01) C07D 213/75(2006.01) C07D 401/04(2006.01) C07D 213/64(2006.01) C07D 231/12(2006.01) C07D 401/06(2006.01) C07D 473/18(2006.01) C07D 285/135(2006.01) C07D 213/74(2006.01) C07D 213/84(2006.01) C07D 233/90(2006.01) (86) International application number: PCT/US2008/084193 (87) International publication number: WO 2009/067600 (28.05.2009 Gazette 2009/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 21.11.2007 US 989551 P (71) Applicant: Decode Genetics EHF 101 Reykjavik (IS)

(72) Inventors: SINGH, Jasbir Naperville Illinois 60564 (US) GURNEY, Mark E. Grand Rapids Michigan 49506 (US) BURGIN, Alex Kingston Washington 98346 (US) SANDANAYAKA, Vincent Northboro Massachusetts 01532 (US) KISELYOV, Alexander San Diego California 92130 (US) MOTTA, Adalie Naperville Illinois 60564 (US) SCHULTZ, Gary Naperville Illinois 60540 (US) HATEGAN, Georgeta Naperville Illinois 60565 (US) HAGEN, Timothy Lisle Illinois 00006-0532 (US) (74) Representative: Graf von Stosch, Andreas et al Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22 80538 München 80538 München (DE)