(19)
(11) EP 2 223 921 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
20.02.2013 Bulletin 2013/08

(45) Mention of the grant of the patent:
09.01.2013 Bulletin 2013/02

(21) Application number: 10003376.0

(22) Date of filing: 24.01.2006
(51) International Patent Classification (IPC): 
C07D 417/04(2006.01)
C07D 413/04(2006.01)
C07D 403/04(2006.01)
C07D 407/04(2006.01)
A61K 31/41(2006.01)
A61K 31/425(2006.01)
 C07D 417/14(2006.01)
C07D 413/14(2006.01)
C07D 405/04(2006.01)
C07D 409/04(2006.01)
A61K 31/42(2006.01)

(54)

2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents

2-Thiophen-2-yl-oxazol-, 2-Thiophen-2-yl-thiazol- und 2-Thiophen-2-yl-1H-imidazol-Derivate als antivirale Wirkstoffe

Dérivés de 2-Thiophén-2-yl-oxazole, 2-Thiophén-2-yl-thiazole et 2-Thiophén-2-yl-1H-imidazole en tant que agents antivirales

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 18.03.2005 CN 200510024468

(43) Date of publication of application:
01.09.2010 Bulletin 2010/35

(62) Application number of the earlier application in accordance with Art. 76 EPC:
06705545.9 / 1889843

(73) Proprietor: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Shanghai 201203 (CN)

(72) Inventors:
  • Nan, Fajun
    Pudong New Shangai 201203 (CN)
  • Zuo, Jianping
    Pudong New Shangai 201203 (CN)
  • Wang, Wenlong
    Pudong New Shangai 201203 (CN)
  • Wang, Guifeng
    Pudong New Shangai 201203 (CN)
  • Chen, Haijun
    Pudong New Shangai 201203 (CN)
  • He, Peilan
    Pudong New Shangai 201203 (CN)

(74) Representative: Flaccus, Rolf-Dieter 
Flaccus · Müller-Wolff Patentanwälte Bussardweg 10
50389 Wesseling
50389 Wesseling (DE)


(56) References cited: : 
WO-A2-2004/005264
   
  • DAVIES ET AL: "NH-insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles" TETRAHEDRON, vol. 60, no. 18, 2004, pages 3967-3977, XP002589138 ISSN: 0040-4020 DOI: 10.1016/j.tet.2004.03.037
  • STOYANOV ET AL: "Investigations of 2-substituted imidazoles. 2. Synthesis and electrophilic substitution of 1-methyl-2-(thienyl-2)imidazole. A convenient method of methylation of 2-R-imidazoles" CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 27, no. 10, 1991, pages 1140-1144, XP002589139 ISSN: 0009-3122 DOI: 10.1007/BF00486814
  • KURAPOY ET AL: "Configuration of 2-(2-thienyl)-5-aryloxazoles in their ground and excited states" CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 25, no. 3, 1989, pages 319-325, XP002589140 ISSN: 0009-3122 DOI: 10.1007/BF00472394
  • CHAUVIN ET AL: "OBTENTION DE POLYHETEROCYCLES A NOYAUX SUBSTITUES" BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1974, pages 2079-2085, XP009135423 ISSN: 0037-8968
  • MORVIK ET AL: "A Practical Approach to the Synthesis of 2,4-Disubstituted Oxazoles from Amino Acids" ORGANIC LETTERS, vol. 4, no. 16, 1974, pages 2665-2668, XP002589142 ISSN: 1523-7060 DOI: 10.1021/ol020092s
   
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