ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSKBAHRIS..MTNORS......................JDIM360 Ver 2.40 (30 Jan 2013) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification201303282233135CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120130710W172deBibliographieenBibliographyfrBibliographieEP09015563.1200810162009121620111026enenen0729127320071019EP989507 P20071121US2013071020132820100929201039201206272012262012012720130710201328A61K 31/00 20060101AFI20100805BHEP A61K 31/138 20060101ALI20100805BHEP A61K 31/18 20060101ALI20100805BHEP A61K 31/222 20060101ALI20100805BHEP A61K 31/404 20060101ALI20100805BHEP A61K 31/4045 20060101ALI20100805BHEP A61K 31/4704 20060101ALI20100805BHEP A61K 31/5377 20060101ALI20100805BHEP A61K 31/36 20060101ALI20100805BHEP A61P 35/00 20060101ALI20100805BHEP deVerwendung von Beta-blockern für die Herstellung eines Medikaments zur Behandlung von HämangiomenenUse of a beta blocker for the manufacture of a medicament for the treatment of hemangiomasfrUtilisation de bêtabloquants pour la fabrication d'un médicament pour le traitement d'hémangiomesWO-A-97/40830WO-A-2006/015830WO-A1-2006/122007AH-FAT F G ET AL: "Recurrent visual loss secondary to an iris microhaemangioma [1]" EYE 1994 GB, vol. 8, no. 3, 1994, page 357, XP008089190 ISSN: 0950-222XGOODFIELD M J ET AL: "The clinical presentation of cutaneous angiolipomata and the response to beta-blockade." 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CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 OCT 2003 LNKD- PUBMED:14555525, vol. 9, no. 12, 1 October 2003 (2003-10-01), pages 4514-4521, XP002590205 ISSN: 1078-0432THAKER PREMAL H ET AL: "Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma" NATURE MEDICINE, vol. 12, no. 8, August 2006 (2006-08), pages 939-944, XP002590206 ISSN: 1078-8956RAZON MARIA J ET AL: "Increased apoptosis coincides with onset of involution in infantile hemangioma" MICROCIRCULATION (PHILADELPHIA), vol. 5, no. 2-3, September 1998 (1998-09), pages 189-195, XP002590207 ISSN: 1073-9688SMITH SALLY K SOMMERS ET AL: "Beta blockade induces apoptosis in cultured capillary endothelial cells" IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY ANIMAL, vol. 38, no. 5, May 2002 (2002-05), pages 298-304, XP002590208 ISSN: 1071-2690BAGHESTANIAN M: "The role of beta-adrenergic blockers as antihypertensive medication in patients with peripheral arterial disease" ZEITSCHRIFT FUR GEFASSMEDIZIN 2006 AT, vol. 3, no. 2, 2006, pages 11-16, XP002590209LÉAUTÉ-LABRÈZE CHRISTINE ET AL: "Propranolol for severe hemangiomas of infancy." 12 June 2008 (2008-06-12), THE NEW ENGLAND JOURNAL OF MEDICINE 12 JUN 2008, VOL. 358, NR. 24, PAGE(S) 2649 - 2651 , XP002523408 ISSN: 1533-4406 * the whole document *BONIFAZI E ET AL: "Propranolol in rapidly growing hemangiomas" 2008, EUROPEAN JOURNAL OF PEDIATRIC DERMATOLOGY 2008 IT, VOL. 18, NR. 3, PAGE(S) 185 - 192 , XP008105082 ISSN: 1122-7672 * abstract * * page 185, column 1, paragraph 2 - page 186, column 2, paragraph 2l * * page 186 * * page 192, column 1, paragraph 1 - column 2, paragraph 1 *CREMER H -J: "Propranolol: A milestone in the treatment of problematic hemangiomas?" October 2008 (2008-10), MONATSSCHRIFT FUR KINDERHEILKUNDE 200810 DE, VOL. 156, NR. 10, PAGE(S) 942 - 943 , XP002523410 ISSN: 0026-9298 * page 942 *LEAUTE-LABREZE C ET AL: "Efficacy of beta-blockers in infantile capillary haemangiomas: The physiopathological significance and therapeutic consequences" December 2008 (2008-12), ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, VOL. 135, NR. 12, PAGE(S) 860-862 , XP008105076 ISSN: 0151-9638 * page 860 - page 861, column 1, last paragraph *BLANCHET CATHERINE ET AL: "Management of infantile subglottic hemangioma: acebutolol or propranolol?", INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY AUG 2010 LNKD- PUBMED:20557953, vol. 74, no. 8, August 2010 (2010-08), pages 959-961, ISSN: 1872-8464POPE ELENA ET AL: "Topical timolol gel for infantile hemangiomas: a pilot study.", ARCHIVES OF DERMATOLOGY MAY 2010 LNKD- PUBMED:20479314, vol. 146, no. 5, May 2010 (2010-05), pages 564-565, ISSN: 1538-3652AKRAM I ET AL: "Iris microhaemangioma presenting with total hyphaema and elevated intraocular pressure.", EYE (BASINGSTOKE), vol. 17, no. 6, August 2003 (2003-08), pages 784-785, ISSN: 0950-222XKHAN ZIA A ET AL: "Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice", JOURNAL OF CLINICAL INVESTIGATION, vol. 118, no. 7, July 2008 (2008-07), pages 2592-2599, ISSN: 0021-9738RITTER MATTHEW R ET AL: "Pathogenesis of infantile haemangioma: new molecular and cellular insights", EXPERT REVIEWS IN MOLECULAR MEDICINE, vol. 9, no. 32, November 2007 (2007-11), ISSN: 1462-3994SUNDINE MICHAEL J ET AL: "Hemangiomas: an overview.", CLINICAL PEDIATRICS APR 2007 LNKD- PUBMED:17416876, vol. 46, no. 3, April 2007 (2007-04), pages 206-221, ISSN: 0009-9228FITZGERALD PAUL J: "Testing whether drugs that weaken norepinephrine signaling prevent or treat various types of cancer.", CLINICAL EPIDEMIOLOGY 2010 LNKD- PUBMED:20865096, vol. 2, 2010, pages 1-3, ISSN: 1179-1349Orfanos Garbe: "Therapie der Hautkrankheiten", 2002, Springer-Verlag, Berlin pages 717-718,GOODFIELD M J D ET AL: "The clinical presentation of cutaneous angiolipomata and the response to beta-blockade", CLINICAL AND EXPERIMENTAL DERMATOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, GB, vol. 13, no. 3, 1 January 1988 (1988-01-01), pages 190-192, XP008089157, ISSN: 0307-6938, DOI: 10.1111/J.1365-2230.1988.TB01968.X08838691.7218787820081016Léauté-Labréze, Christine8, Rue des Palombes33185 Le HaillanFRDumas de la Roque, Éric4 rue du Capitaine Gilles33140 Villenave d'OrnonFRTaieb, Alain2 rue Lenôtre33000 BordeauxFRThambo, Jean-Benoit15 rue de Strasbourg33000 BordeauxFRUniversité Bordeaux Segalen101251005BIP132335EP01146, rue Léo Saignat33076 Bordeaux CedexFRATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMTNLNOPLPTROSESISKTRCentre Hospitalier Universitaire de Bordeaux101243462BIP132335EP0112 rue Dubernat33404 TalenceFRNovagraaf Technologies100061566122 rue Edouard Vaillant92593 Levallois-Perret CedexFR010120120614EPierre Fabre Dermatologie10131868845 place Abel Gance92100 BoulogneFRATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLTLULVMCMTNLNOPLPTROSESISKTRATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMTNLNOPLPTROSESISKTRAL20091216BA20091216MK20100104RS2009121620100929201039