(19)

(11)

EP 2 234 622 A2

(12)

(88) Date of publication A3: 03.09.2009 (43) Date of publication: 06.10.2010 Bulletin 2010/40 (21) Application number: 08866040.2 (22) Date of filing: 29.12.2008

(51) International Patent Classification (IPC):  A61K 31/70(2006.01) (86) International application number: PCT/US2008/088466 (87) International publication number: WO 2009/086526 (09.07.2009 Gazette 2009/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 28.12.2007 WO PCT/US2007/089124 28.12.2007 US 966851 15.07.2008 US 80841 (71) Applicant: The Salk Institute for Biological Studies La Jolla, CA 92037-1099 (US)	(72) Inventors: EVANS, Ronald, M. La Jolla CA 92037 (US) NARKAR, Vihang, A. San Diego CA 92130 (US) SHAW, Reuben, J. San Diego CA 92129 (US) DOWNES, Michael San Diego CA 92117 (US) YU, Ruth, T. La Jolla CA 92037 (US) (74) Representative: Clarke, Victoria et al Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP Alder Castle 10 Noble Street London EC2V 7JX London EC2V 7JX (GB)