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(11)

EP 2 234 639 A2

(12)

(88) Date of publication A3: 27.08.2009 (43) Date of publication: 06.10.2010 Bulletin 2010/40 (21) Application number: 08860961.5 (22) Date of filing: 15.12.2008

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C12N 9/18(2006.01) C12Q 1/44(2006.01) C07K 16/40(2006.01) C12N 15/11(2006.01) (86) International application number: PCT/EP2008/067493 (87) International publication number: WO 2009/077479 (25.06.2009 Gazette 2009/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 17.12.2007 US 14275 P (71) Applicant: Novartis AG 4056 Basel (CH)	(72) Inventors: PAIGEN, Beverly Bar Harbor, Maine 04609 (US) STYLIANO, Ioannis, M. Philadelphia, PA 19104 (US) WANG, Xiaosong Belmont, MA 02478 (US) (74) Representative: Vögeli-Lange, Regina  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)