(19)
(11) EP 2 234 642 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.11.2017 Bulletin 2017/44

(45) Mention of the grant of the patent:
27.09.2017 Bulletin 2017/39

(21) Application number: 08854580.1

(22) Date of filing: 26.11.2008
(51) International Patent Classification (IPC): 
A61K 45/00(2006.01)
(86) International application number:
PCT/US2008/084789
(87) International publication number:
WO 2009/070639 (04.06.2009 Gazette 2009/23)

(54)

METHOD OF INCREASING IMMUNOLOGICAL EFFECT

VERFAHREN ZUR VERSTÄRKUNG EINER IMMUNOLOGISCHEN WIRKUNG

MÉTHODE PROPRE À ACCROÎTRE UN EFFET IMMUNOLOGIQUE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 28.11.2007 US 990759 P
29.05.2008 US 56925 P

(43) Date of publication of application:
06.10.2010 Bulletin 2010/40

(73) Proprietor: IRX Therapeutics, Inc.
New York, NY 10065 (US)

(72) Inventors:
  • SIGNORELLI, Kathy, L.
    Kings Park NY 11754 (US)
  • CZYSTOWSKA, Margareta
    Pittsburgh, PA 15232 (US)
  • EGAN, James, E.
    Stony Brook NY 11790 (US)
  • BRANDWEIN, Harvey
    East Hills NY 11577 (US)
  • WHITESIDE, Theresa, L.
    Pittsburgh PA 15217 (US)
  • HADDEN, John, W.
    Cold Spring Harbor NY 11724 (US)

(74) Representative: Gill Jennings & Every LLP 
The Broadgate Tower 20 Primrose Street
London EC2A 2ES
London EC2A 2ES (GB)


(56) References cited: : 
WO-A2-03/035004
US-A1- 2005 124 645
US-A1- 2007 065 415
 US-A1- 2003 206 885
US-A1- 2007 031 372
US-A1- 2007 196 335
   
  • VERASTEGUI E ET AL: "A NATURAL CYTOKINE MIXTURE (IRX-2) AND INTERFERENCE WITH IMMUNE SUPPRESSION INDUCED IMMUNE MOBILIZATION AND REGRESSION OF HEAD AND NECK CANCER", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, ELMSFORD,NY, US, vol. 19, no. 11/12, 1 January 1997 (1997-01-01), pages 619-627, XP001205421, ISSN: 0192-0561, DOI: 10.1016/S0192-0561(97)00059-3
  • BARRERA J L ET AL: "Combination immunotherapy of squamous cell carcinoma of the head and neck", ARCHIVES OF OTOLARYNGOLOGY HEAD AND NECK SURGERY, AMERICAN MEDICAL ASSOCIATION, US, vol. 126, no. 3, 1 March 2000 (2000-03-01) , pages 345-351, XP002967974, ISSN: 0886-4470
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).