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EP 2 238 131 A1

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(43) Date of publication: 13.10.2010 Bulletin 2010/41 (21) Application number: 08866782.9 (22) Date of filing: 23.12.2008

(51) International Patent Classification (IPC):  C07D 413/10(2006.01) C07D 271/113(2006.01) A61P 25/00(2006.01) A61P 9/00(2006.01) C07D 413/12(2006.01) A61K 31/4245(2006.01) A61P 11/00(2006.01) (86) International application number: PCT/PT2008/000054 (87) International publication number: WO 2009/084970 (09.07.2009 Gazette 2009/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 27.12.2007 US 9302 (71) Applicant: BIAL - Portela & Ca., S.A. À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado (PT)

(72) Inventors: LEARMONTH, David Alexander P-4445-123 Alfena (PT) KISS, Laszlo Erno P-4455-104 Lavra (PT) BELIAEV, Alexander P-4485-546 Mindelo (PT) FERREIRA, Humberto dos Santos P-4445-172 Alfena (PT) SILVA, Patrício Manuel Vieira Araújo Soares da P-4150-049 Porto (PT) (74) Representative: Bublak, Wolfgang  Bardehle, Pagenberg, Dost, Altenburg, Geissler Galileiplatz 1 81679 München 81679 München (DE)