ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCY..TRBGCZEEHUPLSK..HRIS..MTNO........................JJDIM360 Ver 1.28 (29 Oct 2014) - 2999001/02243474CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120150311W173deBibliographieenBibliographyfrBibliographieEP09005726.6200904232011042720110530enenen2015031120151120101027201043201501212015042014091020150311201511A61K 31/122 20060101AFI20091001BHEP A61P 31/00 20060101ALI20091001BHEP deSchutzwirkung von Thymoquinon in SepsisenProtective effect of thymoquinone in sepsisfrEffet prospecteur de thymoquinone dans la sepsieWO-A-2006/024545US-A1- 2003 060 454EL GAZZAR ET AL: "Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation" BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1770, no. 4, 22 February 2007 (2007-02-22), pages 556-564, XP005900229 ISSN: 0304-4165ALSAIF M A: "Effect of Nigella sativa oil in metabolic responsed to prolonged systemic injury in rats" JOURNAL OF BIOLOGICAL SCIENCES 2008 PK, vol. 8, no. 6, 2008, pages 974-983, XP009118155 ISSN: 1727-3048 1812-5719YILDIZ FAHRETTIN ET AL: "Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver." WORLD JOURNAL OF GASTROENTEROLOGY : WJG 7 SEP 2008, vol. 14, no. 33, 7 September 2008 (2008-09-07), pages 5204-5209, XP002531818 ISSN: 1007-9327EL GAZZAR M A: "Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation" INFLAMMATION RESEARCH ; OFFICIAL JOURNAL OF: THE INTERNATIONAL ASSOCIATION OF INFLAMMATION SOCIETIES THE EUROPEAN HISTAMINE RESEARCH SOCIETY, BIRKHÄUSER-VERLAG, BA, vol. 56, no. 8, 1 August 2007 (2007-08-01), pages 345-351, XP019531449 ISSN: 1420-908XLIU M ET AL: "GROWTH-INHIBITING ACTIVITY OF ANTHRAQUINONES AND BENZOQUINONES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)" DOKKYO JOURNAL OF MEDICAL SCIENCES, MIBU, JP, vol. 23, no. 2, 1 January 1996 (1996-01-01), pages 85-93, XP000908978 ISSN: 0385-5023LAI P K ET AL: "Antimicrobial and chemopreventive properties of herbs and spices" CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 11, no. 11, 1 June 2004 (2004-06-01), pages 1451-1460, XP009117713 ISSN: 0929-8673ALJABRE S H M ET AL: "Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone" JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER SCIENTIFIC PUBLISHERS LTD, IE, vol. 101, no. 1-3, 3 October 2005 (2005-10-03), pages 116-119, XP025270010 ISSN: 0378-8741 [retrieved on 2005-10-03]SHIGEHARU INOUYE ET AL: "Evaluation of the effect of terpenoid quinones on Trichophyton mentagrophytes by solution and vapor contact" JOURNAL OF INFECTION AND CHEMOTHERAPY ; OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF CHEMOTHERAPY AND THE JAPANESE ASSOCIATION FORINFECTIOUS DISEASES, SPRINGER-VERLAG, TO, vol. 12, no. 2, 1 April 2006 (2006-04-01), pages 100-104, XP019374935 ISSN: 1437-7780EL-DAKHAKHNY MOHAMED ET AL: "Protective effect of Nigella sativa oil and clindamycin against production of tumor necrosis factor-alpha and liver injury in murine septic peritonitis" NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 362, no. 4-5 Supplement, 2000, page R17, XP009118158 & ANPT-SYMPOSIUM; BERLIN-DAHLEM, GERMANY; SEPTEMBER 27, 2000 ISSN: 0028-1298ALI B H ET AL: "Pharmacological and toxicological properties of Nigella sativa", PHYTOTHERAPY RESEARCH, JOHN WILEY & SONS LTD. CHICHESTER, GB, vol. 17, no. 4, 1 January 2003 (2003-01-01), pages 299-305, XP002538026, ISSN: 0951-418X, DOI: 10.1002/PTR.1309COHEN J ET AL: "INTERSEPT: AN INTERNATIONAL, MULTICENTER, PLACEBO-CONTROLLED TRIAL OF MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR-ALPHA PATIENTS WITH SEPSIS", CRITICAL CARE MEDICINE,, vol. 24, no. 9, 1 September 1996 (1996-09-01), pages 1431-1440, XP000655200, ISSN: 0090-3493, DOI: 10.1097/00003246-199609000-00002ABRAHAM E ET AL: "Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock", THE LANCET, LANCET LIMITED. LONDON, GB, vol. 351, no. 9107, 8 March 1998 (1998-03-08), pages 929-933, XP004266935, ISSN: 0140-6736DHAINAUT J F ET AL: "CDP571, a humanized antibody to human tumor necrosis factor-alpha: safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group", CRITICAL CARE MEDICINE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 23, no. 9, 1 September 1995 (1995-09-01), pages 1461-1469, XP009178281, ISSN: 0090-3493Charles J. Fisher ET AL: "Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein", New England Journal of Medicine, vol. 334, no. 26, 27 June 1996 (1996-06-27), pages 1697-1702, XP055121181, ISSN: 0028-4793, DOI: 10.1056/NEJM199606273342603Alkharfy, KhalidDept. of Clinical Pharmacy College of Pharmacy Kind Saud UniversityRiyadh 11451SAAl-Daghri, Nasser M.Dept. Boichemistry, College of Science King Saud UniversityRiyadh 11451SAAl-Attas, Omar S.Dept. Biochemistry, College of Science King Saud UniversityRiyadh 11451SAAlokail, Majed S.P.O. Box 92447Riyadh 11653SAKing Saud University101146442FB21444P.O. Box 80011421 RiyadhSAEngelhard, Markus101156514Boehmert & Boehmert Anwaltspartnerschaft mbB Patentanwälte Rechtsanwälte Pettenkoferstrasse 20-2280336 MünchenDEATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTROSESISKTR20101027201043