| (19) |
 |
|
(11) |
EP 2 251 034 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
|
Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
|
Corrected version no 1 (W1 A1) |
| (48) |
Corrigendum issued on: |
|
29.06.2011 Bulletin 2011/26 |
| (43) |
Date of publication: |
|
17.11.2010 Bulletin 2010/46 |
| (22) |
Date of filing: 01.12.2006 |
|
| (51) |
International Patent Classification (IPC):
|
|
| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE
SI SK TR |
|
Designated Extension States: |
|
AL BA HR MK RS |
| (30) |
Priority: |
02.12.2005 US 741833 P
22.05.2006 US 802864 P
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
06838693.7 / 1962893 |
| (71) |
Applicant: Mount Sinai School of Medicine |
|
New York, NY 10029-6574 (US) |
|
| (72) |
Inventors: |
|
- Palese, Peter
Leonia, NJ 07605 (US)
- Garcia-Sastre, Adolfo
New York, NY 10128 (US)
|
| (74) |
Representative: Weber, Martin |
|
Jones Day
Rechtsanwälte Attorneys-at-Law Patentanwälte
Prinzregentenstrasse 11
80538 München
80538 München (DE) |
|
| |
|
|
|
Remarks: |
|
This application was filed on 18-08-2010 as a divisional application to the application
mentioned under INID code 62. |
|
| (54) |
Chimeric Newcastle Disease viruses presenting non-native surface proteins and uses
thereof |
(57) The present invention provides chimeric negative-stand RNA viruses that allow a subject,
e.g., an avian, to be immunized against two infectious agents by using a single chimeric
virus of the invention. In particular, the present invention provides chimeric Newcastle
Disease viruses (NDV) engineered to express and incorporate into their virions a fusion
protein comprising the ectodomain of a protein of an infectious agent and the transmembrane
and cytoplasmic domain of an NDV protein. Such chimeric viruses induce an immune response
against NDV and the infectious agent.