(19)
(11) EP 2 254 878 A1

(12)

(43) Date of publication:
01.12.2010 Bulletin 2010/48

(21) Application number: 08713963.0

(22) Date of filing: 24.01.2008
(51) International Patent Classification (IPC): 
C07D 311/36(2006.01)
C07D 405/14(2006.01)
C07D 413/14(2006.01)
A61K 31/353(2006.01)
 C07D 405/04(2006.01)
C07D 413/12(2006.01)
C07D 417/12(2006.01)
A61P 25/32(2006.01)
(86) International application number:
PCT/US2008/051862
(87) International publication number:
WO 2009/094028 (30.07.2009 Gazette 2009/31)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA MK RS

(71) Applicants:
  • Gilead Palo Alto, Inc.
    Foster City, CA 94404 (US)
  • The Endowment for Research in Human Biology, Inc.
    Boston, MA 02115 (US)

(72) Inventors:
  • BILOKIN, Yaroslav
    Toronto, Ontario M2N 1X9 (CA)
  • ELZEIN, Elfatih
    Fremont CA 94555 (US)
  • ZABLOCKI, Jeff
    Los Altos, CA 94024 (US)
  • ORGAN, Michael
    Burlington, Ontario L7T1A6 (CA)
  • PERRY, Thao
    San Jose CA 95124 (US)
  • KOBAYASHI, Tetsuya
    Sunnyvale CA 94087 (US)
  • ABELMAN, Matthew
    Mountain View CA 94040 (US)
  • KALLA, Rao
    Sunnyvale CA 94087 (US)
  • FAN, Peidong
    San Francisco CA 94116 (US)
  • DIAMOND, Ivan
    Berkeley CA 94707 (US)
  • JIANG, Robert
    Cupertino, CA 95014 (US)
  • AROLFO, Maria, Pia
    Pleasanton CA 94566 (US)
  • LI, Xiaofen
    Mountain View CA 94040 (US)
  • YAO, Lina
    San Francisco CA 94116 (US)
  • JIANG, Zhan
    San Francisco CA 94116 (US)
  • KEUNG, Wing Ming
    Wayland MA 01778 (US)
  • TAO, Guoxin
    Beijing 100045 (CN)

(74) Representative: Schnappauf, Georg et al
Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6
D-81679 München
D-81679 München (DE)

   


(54) ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION