(19)
(11) EP 2 254 880 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.09.2016 Bulletin 2016/38

(45) Mention of the grant of the patent:
17.08.2016 Bulletin 2016/33

(21) Application number: 09713314.4

(22) Date of filing: 23.02.2009
(51) International Patent Classification (IPC): 
C07D 313/00(2006.01)
A61K 31/365(2006.01)
 C07D 315/00(2006.01)
(86) International application number:
PCT/US2009/034878
(87) International publication number:
WO 2009/105755 (27.08.2009 Gazette 2009/35)

(54)

Macrocyclic prodrug compounds useful as therapeutics

Als Therapeutika geeignete makrocyclische Prodrugverbindungen

Composés de promédicaments macrocycliques utilisés comme agents thérapeutiques

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(30) Priority: 21.02.2008 US 30446 P

(43) Date of publication of application:
01.12.2010 Bulletin 2010/48

(73) Proprietors:
  • OncoSynergy, Inc.
    San Francisco, CA 94158 (US)
  • Université de Strasbourg
    67070 Strasbourg (FR)

(72) Inventors:
  • HECK, James
    New York, NY 10019 (US)
  • WINSSINGER, Nicolas
    F-67000 Strasbourg (FR)
  • CHABALA, John C.
    New York, NY 10019 (US)
  • BARLUENGA, Sofia
    F-67000 Strasbourg (FR)
  • CHEN, Ruihong
    New York, NY 10019 (US)
  • RUBENSTEIN, Allan
    New York, NY 10019 (US)
  • YU, Jin-Chen
    New York, NY 10019 (US)

(74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB 
Siebertstrasse 3
81675 München
81675 München (DE)


(56) References cited: : 
EP-A1- 0 460 950
WO-A1-2004/024142
JP-A- 10 265 381
US-A1- 2005 182 129
 EP-A1- 0 823 429
JP-A- 9 202 781
JP-A- 2003 113 183
   
  • FRANZ BRACHER ET AL.: 'The total synthesis of both enantiomers of the macrocyclic lactone zearalane.' EUR.J.ORG.CHEM. 2001, pages 4701 - 4704, XP008141388
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).