(19)
(11) EP 2 261 363 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A2)

(48) Corrigendum issued on:
16.02.2011 Bulletin 2011/07

(43) Date of publication:
15.12.2010 Bulletin 2010/50

(21) Application number: 10009228.7

(22) Date of filing: 17.12.2008
(51) International Patent Classification (IPC): 
C12N 15/82(2006.01)
C12N 5/10(2006.01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA MK RS

(30) Priority: 18.12.2007 US 14512 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
08862105.7 / 2229447

(71) Applicant: E. I. du Pont de Nemours and Company
Wilmington, DE 19898 (US)

(72) Inventor:
  • McGonigle, Brian
    Wilmington Delaware 19806-2501 (US)

(74) Representative: Dzieglewska, Hanna Eva 
Dehns St Bride's House 10 Salisbury Square
London EC4Y 8JD
London EC4Y 8JD (GB)

 
Remarks:
This application was filed on 06-09-2010 as a divisional application to the application mentioned under INID code 62.
 


(54) Down-regulation of gene expression using artificial microRNAs


(57) Isolated nucleic acid fragments comprising precursor miRNAs, and artificial miRNAs and their use in down-regulating gene expression are described.