(19)
(11) EP 2 262 778 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.01.2020 Bulletin 2020/01

(45) Mention of the grant of the patent:
21.08.2019 Bulletin 2019/34

(21) Application number: 09718483.2

(22) Date of filing: 05.03.2009
(51) International Patent Classification (IPC): 
C07D 231/54(2006.01)
A61K 31/416(2006.01)
A61P 3/10(2006.01)
A61P 13/00(2006.01)
 C07D 401/12(2006.01)
A61K 31/435(2006.01)
A61P 9/00(2006.01)
(86) International application number:
PCT/EP2009/052588
(87) International publication number:
WO 2009/109616 (11.09.2009 Gazette 2009/37)

(54)

1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40

1-BENZYL-3-HYDROXYMETHYLINDAZOLDERIVATE UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON AUF DER EXPRESSION VON MCP-1, CX3CR1 UND P40 BASIERTEN ERKRANKUNGEN

DÉRIVÉS DE 1-BENZYL-3-HYDROXYMÉTHYLINDAZOLE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES BASÉES SUR L'EXPRESSION DE MCP-1, CX3CR1 ET P40

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(30) Priority: 07.03.2008 EP 08425140

(43) Date of publication of application:
22.12.2010 Bulletin 2010/51

(73) Proprietor: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
00181 Roma (IT)

(72) Inventors:
  • GUGLIELMOTTI, Angelo
    00149 Roma (IT)
  • FURLOTTI, Guido
    00151 Roma (IT)
  • MANGANO, Giorgina
    00139 Roma (IT)
  • CAZZOLLA, Nicola
    00041 Albano Laziale (Roma) (IT)

(74) Representative: Colombo, Stefano Paolo et al
Marchi & Partners S.r.l. Via Vittor Pisani, 13
20124 Milano
20124 Milano (IT)


(56) References cited: : 
WO-A-99/04770
CN-A- 101 074 208
US-A1- 2007 043 057
 WO-A1-2008/052898
US-A1- 2006 047 126
   
  • HENKE B R ET AL: "Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepi nes as potent, orally active CCK-A agonists" JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 40, no. 17, 15 August 1997 (1997-08-15), pages 2706-2725, XP002105882 ISSN: 0022-2623 cited in the application
  • CORSI, G. ET AL.: "1-halobenzyl-1H-indazoles-3-carboxylic acids. A new class of antispermatogenic agents" JOURNAL OF MEDICINAL CHEMISTRY, vol. 19, no. 6, 1976, pages 778-783, XP002493577 cited in the application
   
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