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EP 2 262 837 A2

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(88) Date of publication A3: 03.06.2010 (43) Date of publication: 22.12.2010 Bulletin 2010/51 (21) Application number: 09719690.1 (22) Date of filing: 03.03.2009

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12P 21/08(2006.01) (86) International application number: PCT/US2009/035825 (87) International publication number: WO 2009/114335 (17.09.2009 Gazette 2009/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 12.03.2008 US 69060 P (71) Applicant: Merck Sharp & Dohme Corp. Rahway, NJ 07065 (US)

(72) Inventors: FINNEFROCK, Adam, C. Rahway New Jersey 07065-0907 (US) FU, Tong-Ming Rahway New Jersey 07065-0907 (US) FREED, Daniel, C. Rahway New Jersey 07065-0907 (US) CASIMIRO, Danilo, R. Rahway New Jersey 07065-0907 (US) LI, Fengsheng Rahway New Jersey 07065-0907 (US) TANG, Aimin Rahway New Jersey 07065-0907 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc. European Patent Department Merck Sharpe & Dohme Limited Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)