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(11)

EP 2 271 646 A1

(12)

(43) Date of publication: 12.01.2011 Bulletin 2011/02 (21) Application number: 09728425.1 (22) Date of filing: 30.03.2009

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 25/28(2006.01) A61P 9/00(2006.01) A61P 35/00(2006.01) A61K 31/519(2006.01) A61P 3/00(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/US2009/038840 (87) International publication number: WO 2009/123986 (08.10.2009 Gazette 2009/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 31.03.2008 US 41166 (71) Applicant: Takeda Pharmaceutical Company Limited Osaka 541-0045 (JP)	(72) Inventors: CHANG, Edcon San Diego CA 92127-3712 (US) DUONG, Tracy San Diego CA 92104 (US) HIRANO, Takehiro Osaka-shi Osaka 532-8686 (JP) MCNEILL, Matthew, H. San Clemente CA 92673 (US) TERAO, Yoshito Osaka-shi Osaka 532-8686 (JP) VASSAR, Angie San Diego, CA 92128 (US) (74) Representative: Duncan, Garreth Andrew et al D Young & Co LLP 120 Holborn London EC1N 2DY London EC1N 2DY (GB)