(19)
(11) EP 2 273 996 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.04.2017 Bulletin 2017/17

(45) Mention of the grant of the patent:
22.02.2017 Bulletin 2017/08

(21) Application number: 09726362.8

(22) Date of filing: 25.03.2009
(51) International Patent Classification (IPC): 
C12N 5/077(2010.01)
A61P 9/00(2006.01)
A61K 35/12(2015.01)
(86) International application number:
PCT/US2009/038220
(87) International publication number:
WO 2009/120762 (01.10.2009 Gazette 2009/40)

(54)

HUMAN CARDIOVASCULAR PROGENITOR CELLS

HUMANE KARDIOVASKULÄRE VORLÄUFERZELLEN

CELLULES PROGÉNITRICES CARDIO-VASCULAIRES HUMAINES


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(30) Priority: 27.03.2008 US 40049

(43) Date of publication of application:
19.01.2011 Bulletin 2011/03

(73) Proprietor: Icahn School of Medicine at Mount Sinai
New York, NY 10029-6574 (US)

(72) Inventors:
  • KELLER, Gordon
    Toronto Ontario M4W 2E6 (CA)
  • YANG, Lei
    New York, NY 10029 (US)
  • KATTMAN, Steven
    Toronto Ontario M4W 1P1 (CA)

(74) Representative: Gardner, Rebecca Katherine 
Dehns St Bride's House 10 Salisbury Square
London EC4Y 8JD
London EC4Y 8JD (GB)


(56) References cited: : 
WO-A1-2007/002358
US-A1- 2005 214 939
WO-A2-2007/002385
   
  • MESSINA ELISA ET AL: "Isolation and expansion of adult cardiac stem cells from human and murine heart", CIRCULATION RESEARCH, vol. 95, no. 9, 29 October 2004 (2004-10-29), pages 911-921, XP002477755, AMERICAN HEART ASSOCIATION, INC, US ISSN: 1524-4571, DOI: 10.1161/01.RES.0000147315.71699.51
  • GOUMANS M J ET AL: "TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro", STEM CELL RESEARCH, ELSEVIER, NL, vol. 1, no. 2, 12 March 2008 (2008-03-12), pages 138-149, XP022764784, ISSN: 1873-5061, DOI: 10.1016/J.SCR.2008.02.003 [retrieved on 2008-03-12] -& GOUMANS M J ET AL: "TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro", STEM CELL RESEARCH, ELSEVIER, NL, vol. 1, no. 2 12 March 2008 (2008-03-12), pages 1-11, XP002660160, Retrieved from the Internet: URL:http://www.sciencedirect.com/science/a rticle/pii/S1873506108000068 [retrieved on 2011-09-26]
  • E. M. F. VAN CRAENENBROECK ET AL: "A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile", JOURNAL OF APPLIED PHYSIOLOGY, vol. 104, no. 4, 24 January 2008 (2008-01-24), pages 1006-1013, XP055008241, ISSN: 8750-7587, DOI: 10.1152/japplphysiol.01210.2007
  • G. P. FADINI ET AL: "Peripheral Blood CD34+KDR+ Endothelial Progenitor Cells Are Determinants of Subclinical Atherosclerosis in a Middle-Aged General Population", STROKE, vol. 37, no. 9, 1 September 2006 (2006-09-01), pages 2277-2282, XP055008242, ISSN: 0039-2499, DOI: 10.1161/01.STR.0000236064.19293.79
  • KATTMAN ET AL.: 'Multipotent Flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages' DEVELOPMENT CELL vol. 11, 2006, pages 723 - 732, XP002491235
  • ROSENBLATT-VELIN ET AL.: 'FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes' J CLIN INVEST vol. 115, 2005, pages 1724 - 1733, XP008143869
  • RAE PETER C ET AL: "Angiogenic potential of endothelial progenitor cells and embryonic stem cells.", VASCULAR CELL 2011, vol. 3, 2011, page 11, ISSN: 2045-824X
  • CHUNG YOUNG ET AL: "Human embryonic stem cell lines generated without embryo destruction.", CELL STEM CELL 7 FEB 2008, vol. 2, no. 2, 7 February 2008 (2008-02-07), pages 113-117, ISSN: 1875-9777
  • YANG LEI ET AL: "Human cardiovascular progenitor cells develop from a KDR plus embryonic-stem-cell-derived population", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 453, no. 7194, 22 May 2008 (2008-05-22), pages 524-529, XP002561095, ISSN: 0028-0836, DOI: 10.1038/NATURE06894 [retrieved on 2008-04-23]
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).