(19)
(11) EP 2 274 335 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
17.06.2015 Bulletin 2015/25

(45) Mention of the grant of the patent:
13.05.2015 Bulletin 2015/20

(21) Application number: 09722394.5

(22) Date of filing: 16.03.2009
(51) International Patent Classification (IPC): 
C07K 16/10(2006.01)
G01N 33/569(2006.01)
 A61P 31/16(2006.01)
G01N 33/577(2006.01)
(86) International application number:
PCT/IB2009/051068
(87) International publication number:
WO 2009/115972 (24.09.2009 Gazette 2009/39)

(54)

MONOCLONAL ANTIBODIES CAPABLE OF REACTING WITH A PLURALITY OF INFLUENZA VIRUS A SUBTYPES

MONOKLONALE ANTIKÖRPER, DIE DAZU IN DER LAGE SIND, MIT MEHREREN SUBTYPEN DES INFLUENZA VIRUS A ZU REAGIEREN

ANTICORPS MONOCLONAUX CAPABLES DE RÉAGIR AVEC UNE PLURALITÉ DE SOUS-TYPES DU VIRUS A DE LA GRIPPE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA RS

(30) Priority: 17.03.2008 IT TO20080204

(43) Date of publication of application:
19.01.2011 Bulletin 2011/03

(73) Proprietor: Pomona Ricerca S.r.l.
10128 Torino (IT)

(72) Inventors:
  • BURIONI, Roberto
    I-47900 Rimini (IT)
  • CLEMENTI, Massimo
    I-20129 Milano (IT)

(74) Representative: Comoglio, Elena et al
Jacobacci & Partners S.p.A. Corso Emilia 8
10152 Torino
10152 Torino (IT)


(56) References cited: : 
EP-A- 0 675 199
WO-A-2007/134327
 WO-A-02/46235
   
  • T. ZIEGLER ET AL.: "Type- and subtype-specific detection of influenza viruses in clinical specimens by rapid culture assay." JOURNAL OF CLINICAL MICROBIOLOGY, vol. 33, no. 2, February 1995 (1995-02), pages 318-321, XP002541924
  • Y. SMIRNOV ET AL.: "An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influenza A virus." ACTA VIROLOGICA, vol. 43, no. 4, 1 August 1999 (1999-08-01), pages 237-244, XP009095964 Prague
  • Y. SMIRNOV ET AL.: "Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using a monoclonal antibody against conserved epitope in the HA stem region." ARCHIVES OF VIROLOGY, vol. 145, no. 8, January 2000 (2000-01), pages 1733-1741, XP002473326 Vienna
  • M. THROSBY ET AL.: "Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells." PLOS ONE, vol. 3, no. 12(e3942), 16 December 2008 (2008-12-16), pages 1-15, XP002541925 U.S.A.
  • E. HERNANDEZ ET AL.: "Compared protective effect of nasal immunoprophylaxis using a new human monoclonal IgM antibody, human polyclonal antibodies, F(ab')2, amantadine, and zanamivir for prophylaxis of influenza A virus pneumonia in mice.", MILITARY MEDICINE, vol. 168, no. 3, March 2003 (2003-03), pages 246-251,
  • S. WARD ET AL.: "Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli.", NATURE, vol. 341, 12 October 1989 (1989-10-12), pages 544-546,
  • D. BURTON ET AL.: "Vaccines and the induction of functional antibodies: Time to look beyond the molecules of natural infection?", NATURE MEDICINE, vol. 6, no. 2, February 2000 (2000-02), pages 123-125,
  • R. BURIONI ET AL.: "Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site.", PLOS ONE, vol. 3, no. 10, October 2008 (2008-10), page e3423,
  • R. BURIONI ET AL.: "Cross-reactive pseudovirus-neutralizing anti-envelope antibodies coexist with antibodies devoid of such activity in persistent hepatitis C virus infection.", VIROLOGY, vol. 327, 2004, pages 242-248,
  • N. MANCINI ET AL.: "Modulation of epitope-specific anti-hepatitis C virus E2 (anti-HCV/E2) antibodies by anti-viral treatment.", JOURNAL OF MEDICAL VIROLOGY, vol. 78, 2006, pages 1304-1311,
  • J. DAVIES & L. RIECHMANN: "Antibody VH domains as small recognition units.", BIOTECHNOLOGY, vol. 13, no. 5, May 1995 (1995-05), pages 475-479, XP002011336, New York, USA
  • Y. REITER ET AL.: "An antibody single-domain phage display library of a native heavy chain variable region: Isolation of functional single-domain VH molecules with a unique interface.", JOURNAL OF MOLECULAR BIOLOGY, vol. 290, no. 3, 1999, pages 685-698, UK
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).