(19)

(11)

EP 2 274 443 A2

(12)

(88) Date of publication A3: 04.03.2010 (43) Date of publication: 19.01.2011 Bulletin 2011/03 (21) Application number: 09729900.2 (22) Date of filing: 09.04.2009

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) G01N 33/68(2006.01) G01N 33/53(2006.01) (86) International application number: PCT/US2009/040106 (87) International publication number: WO 2009/126828 (15.10.2009 Gazette 2009/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 09.04.2008 US 123478 P (71) Applicants: California Institute of Technology Pasadena, CA 91125 (US) The Regents Of The University Of California Oakland, CA 94607 (US)	(72) Inventors: KWONG, Gabriel, A. Alhambra, CA 91803 (US) RADU, Caius, G. Los Angeles, CA 90024 (US) RIBAS, Antoni Los Angeles, CA 90024 (US) WITTE, Owen Sherman Oaks, CA 91403 (US) HEATH, James, R. South Pasadena, CA 91030 (US) (74) Representative: Williams, Richard Andrew Norman  Harrison Goddard Foote 40-43 Chancery Lane GB-London WC2A 1JA GB-London WC2A 1JA (GB)