(19)
(11) EP 2 276 756 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
11.04.2012 Bulletin 2012/15

(45) Mention of the grant of the patent:
30.11.2011 Bulletin 2011/48

(21) Application number: 09726601.9

(22) Date of filing: 02.04.2009
(51) International Patent Classification (IPC): 
C07D 401/12(2006.01)
C07D 417/12(2006.01)
C07D 487/04(2006.01)
A61K 31/4178(2006.01)
 C07D 403/12(2006.01)
C07D 471/04(2006.01)
A61P 13/00(2006.01)
A61K 31/506(2006.01)
(86) International application number:
PCT/US2009/039253
(87) International publication number:
WO 2009/124167 (08.10.2009 Gazette 2009/41)

(54)

HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS

HYDROXYMETHYL-PYRROLIDINE ALS BETA-3-ADRENERGE REZEPTORAGONISTEN

HYDROXYMÉTHYL PYRROLIDINES EN TANT QU`AGONISTES DE RÉCEPTEUR BÊTA 3 ADRÉNERGIQUE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA RS

(30) Priority: 04.04.2008 US 123063 P
27.01.2009 US 206043 P

(43) Date of publication of application:
26.01.2011 Bulletin 2011/04

(73) Proprietor: Merck Sharp & Dohme Corp.
Rahway, NJ 07065 (US)

(72) Inventors:
  • BERGER, Richard
    Rahway NJ 07065-0907 (US)
  • CHANG, Lehua
    Rahway NJ 07065-0907 (US)
  • EDMONDSON, Scott, D.
    Rahway NJ 07065-0907 (US)
  • GOBLE, Stephen, D.
    Rahway NJ 07065-0907 (US)
  • HA, Sookhee, Nicole
    Rahway NJ 07065-0907 (US)
  • KAR, Nam, Fung
    Rahway NJ 07065-0907 (US)
  • KOPKA, Ihor, E.
    Rahway NJ 07065-0907 (US)
  • LI, Bing
    Rahway NJ 07065-0907 (US)
  • MORRIELLO, Gregori, J.
    Rahway NJ 07065-0907 (US)
  • MOYES, Chris, R.
    Rahway NJ 07065-0907 (US)
  • SHEN, Dong-Ming
    Rahway NJ 07065-0907 (US)
  • WANG, Liping
    Rahway NJ 07065-0907 (US)
  • ZHU, Cheng
    Rahway NJ 07065-0907 (US)

(74) Representative: Horgan, James Michael Frederic 
Merck & Co., Inc. European Patent Department Merck Sharpe & Dohme Limited Hertford Road
Hoddesdon Hertfordshire EN11 9BU
Hoddesdon Hertfordshire EN11 9BU (GB)


(56) References cited: : 
US-A1- 2002 028 835
 US-A1- 2007 185 136
   
       
    Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).