(19)

(11)

EP 2 276 879 A2

(12)

(88) Date of publication A3: 17.12.2009 (43) Date of publication: 26.01.2011 Bulletin 2011/04 (21) Application number: 09730154.3 (22) Date of filing: 10.04.2009

(51) International Patent Classification (IPC):  D01F 1/10(2006.01) A61L 15/32(2006.01) D01D 5/00(2006.01) A61F 13/02(2006.01) (86) International application number: PCT/US2009/040182 (87) International publication number: WO 2009/126870 (15.10.2009 Gazette 2009/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 11.04.2008 US 44165 P (71) Applicants: Virginia Commonwealth University Richmond, VA 23219 (US) HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. Rockville, MD 20852 (US)	(72) Inventors: BOWLIN, Gary, L. Machanicsville VA 23111 (US) SIMPSON, David, G. Mechanicsville VA 23116 (US) BOWMAN, James, R. Richamond VA 23226 (US) ROTHWELL, Stephen, W. Columbia, MD (US) (74) Representative: Hutchins, Michael Richard  M.R. Hutchins & Co 33 Connaught Way GB-Tunbridge Wells, Kent TN4 9QP GB-Tunbridge Wells, Kent TN4 9QP (GB)