(19)

(11)

EP 2 279 208 A1

(12)

(43) Date of publication: 02.02.2011 Bulletin 2011/05 (21) Application number: 09745745.1 (22) Date of filing: 13.05.2009

(51) International Patent Classification (IPC):  C07K 16/24(2006.01) A61P 37/08(2006.01) A61P 11/06(2006.01) (86) International application number: PCT/EP2009/055745 (87) International publication number: WO 2009/138413 (19.11.2009 Gazette 2009/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 15.05.2008 US 152903 11.12.2008 WO PCT/EP2008/067295 04.03.2009 US 397826 (71) Applicant: Domantis Limited Brentford, Middlesex TW8 9GS (GB)

(72) Inventors: DE SILVA, Inusha Cambridge Cambridgeshire CB4 0WG (GB) DE WILDT, Rudolf, Maria Stevenage Hertfordshire SG2 1NY (GB) DIMECH, Caroline, J Stevenage Hertfordshire SG1 2NY (GB) PUPECKA, Malgorzata Cambridge Cambridgeshire CB4 0WG (GB) SPARKS, Catherine, A Cambridge Cambridgeshire CB4 0WG (GB) (74) Representative: Easeman, Richard Lewis  GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)