(19)
(11) EP 2 280 954 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.05.2013 Bulletin 2013/20

(45) Mention of the grant of the patent:
27.03.2013 Bulletin 2013/13

(21) Application number: 09741870.1

(22) Date of filing: 05.05.2009
(51) International Patent Classification (IPC): 
C07D 401/04(2006.01)
C07D 471/04(2006.01)
A61K 31/4745(2006.01)
 C07D 401/14(2006.01)
A61K 31/4709(2006.01)
A61P 5/40(2006.01)
(86) International application number:
PCT/EP2009/003217
(87) International publication number:
WO 2009/135651 (12.11.2009 Gazette 2009/46)

(54)

6-PYRIDIN-3-YL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN ALDOSTERONE SYNTHASE CYP11B2

6-PYRIDIN-3-YL-3,4-DIHYDRO-1H-CHINOLIN-2-ON-DERIVATE UND ENTSPRECHENDE VERBINDUNGEN ALS HEMMER DER MENSCHLICHEN ALDOSTERONSYNTHASE CYP11B2

DÉRIVÉS DE 6-PYRIDIN-3-YL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE ET COMPOSÉS APPARENTÉS EN TANT QU INHIBITEURS DE L'ALDOSTÉRONE SYNTHASE CYP11B2 HUMAINE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(30) Priority: 06.05.2008 DE 102008022221
08.05.2008 US 51437 P

(43) Date of publication of application:
09.02.2011 Bulletin 2011/06

(73) Proprietor: Elexopharm GmbH
66123 Saarbrücken (DE)

(72) Inventors:
  • HARTMANN, Rolf, W.
    66111 Saarbrücken (DE)
  • HEIM, Ralf
    65189 Wiesbaden (DE)
  • LUCAS, Simon
    52080 Aachen (DE)

(74) Representative: Samson & Partner 
Widenmayerstrasse 5
80538 München
80538 München (DE)


(56) References cited: : 
EP-A- 0 148 623
WO-A-2004/018419
WO-A-2006/113432
US-A1- 2006 069 098
 EP-A- 0 527 534
WO-A-2006/092430
US-A- 4 792 561
US-A1- 2007 249 605
   
  • MARTINEZ ET AL: "3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase" JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 4, 1992, pages 620-628, XP002537465
  • ALABASTER ET AL: "2(1H)-Quinolinones with cardiac stimulant activity. 1. Synthesis and biological activities of (six-membered heteroaryl)-substituted derivatives" JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 10, 1988, pages 2048-2056, XP002537466
  • BELL ET AL: "A Direct Synthesis of 6-Pyridinyl-2(1H)-quinolinones via Palladium-Catalysed Cross-Coupling Reaction" SYNTHESIS, vol. 9, 1987, pages 843-844, XP002537467
  • LECLERC ET AL: "Cardiotonic agents. 2. Synthesis and structure-activity relationships in a new class of 6-, 7-, and 8-pyridyl-2(1H)-quinolone derivatives" JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 12, 1986, pages 2433-2438, XP002537468
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).