(19)

(11)

EP 2 285 828 A1

(12)

(43) Date of publication: 23.02.2011 Bulletin 2011/08 (21) Application number: 09788197.3 (22) Date of filing: 16.06.2009

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) C07K 14/71(2006.01) A61K 48/00(2006.01) C07K 14/705(2006.01) A61K 38/17(2006.01) G01N 33/53(2006.01) (86) International application number: PCT/NL2009/050346 (87) International publication number: WO 2010/005296 (14.01.2010 Gazette 2010/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 16.06.2008 EP 08158319 16.06.2008 US 61741 P (71) Applicant: Nederlands Instituut voor Neurowetenschappen 1105 BA Amsterdam (NL)	(72) Inventors: VERHAAGEN, Joost NL-1312 WP Almere (NL) FRANSSEN, Elske Helena Philomena NL-1051 VP Amsterdam (NL) DE BREE, Frederik Marco NL-3525 TE Utrecht (NL) SMIT, August Benjamin NL-1076 RC Amsterdam (NL) VAN KESTEREN, Ronald Ernst NL-1312 WP Almere (NL) (74) Representative: Swinkels, Bart Willem  Nederlandsch Octrooibureau J. W. Frisolaan 13 2517 JS Den Haag 2517 JS Den Haag (NL)