(19)
(11) EP 2 288 336 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
22.03.2017 Bulletin 2017/12

(45) Mention of the grant of the patent:
07.12.2016 Bulletin 2016/49

(21) Application number: 09735130.8

(22) Date of filing: 24.04.2009
(51) International Patent Classification (IPC): 
A61K 31/7088(2006.01)
A61K 9/51(2006.01)
A61K 9/127(2006.01)
(86) International application number:
PCT/US2009/002540
(87) International publication number:
WO 2009/131704 (29.10.2009 Gazette 2009/44)

(54)

NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL

FÜR DIE VERESTERUNG MIT CHOLESTEROL GEEIGNETE NANOSTRUKTUREN

NANOTRUCTURES ADAPTÉES À LA SÉQUESTRATION DU CHOLESTÉROL


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(30) Priority: 25.04.2008 US 47903 P
22.09.2008 US 98923 P
24.11.2008 US 117350 P
13.03.2009 US 160165 P

(43) Date of publication of application:
02.03.2011 Bulletin 2011/09

(73) Proprietor: Northwestern University
Evanston, IL 60208 (US)

(72) Inventors:
  • MIRKIN, Chad, A.
    Wilmette IL 60091 (US)
  • THAXTON, C., Shad
    Chicago IL 60614 (US)
  • GILJOHANN, David, A.
    Chicago IL 60626 (US)
  • DANIEL, Weston
    Evanston, IL 60201 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)


(56) References cited: : 
WO-A1-92/21330
WO-A2-2006/110350
WO-A2-2008/106660
WO-A1-93/21528
WO-A2-2007/089607
US-A1- 2004 053 384
   
  • NIEMEYER C M ET AL: "Bifunctional DNA-gold nanoparticle conjugates as building blocks for the self-assembly of cross-linked particle layers" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US LNKD- DOI:10.1016/J.BBRC.2003.10.103, vol. 311, no. 4, 28 November 2003 (2003-11-28), pages 995-999, XP004472268 ISSN: 0006-291X
  • HURST SARAH J ET AL: "Maximizing DNA loading on a range of gold nanoparticle sizes" ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC0613582, vol. 78, no. 24, 15 December 2006 (2006-12-15), pages 8313-8318, XP002465378 ISSN: 0003-2700
  • ZHANG ET AL: "A sensitive impedance immunosensor based on functionalized gold nanoparticle-protein composite films for probing apolipoprotein A-I" TALANTA, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.TALANTA.2006.05.081, vol. 71, no. 2, 20 January 2007 (2007-01-20), pages 874-881, XP022345637 ISSN: 0039-9140
  • MUKHERJEE S ET AL: "Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach" CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR LNKD- DOI:10.1016/J.CHEMPHYSLIP.2004.12.001, vol. 134, no. 1, 1 March 2005 (2005-03-01) , pages 79-84, XP004773921 ISSN: 0009-3084
  • THAXTON C SHAD ET AL: "Templated spherical high density lipoprotein nanoparticles." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 4 FEB 2009 LNKD- PUBMED:19133723, vol. 131, no. 4, 4 February 2009 (2009-02-04), pages 1384-1385, XP002587918 ISSN: 1520-5126
  • B S Dhaliwal ET AL: "Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally", Journal of lipid research, 1 October 2000 (2000-10-01), page 1658, XP055120837, UNITED STATES Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/pubmed/110 13308
   
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