(19)

(11)

EP 2 288 622 A2

(12)

(88) Date of publication A3: 14.01.2010 (43) Date of publication: 02.03.2011 Bulletin 2011/09 (21) Application number: 09743241.3 (22) Date of filing: 16.04.2009

(51) International Patent Classification (IPC):  C07K 14/745(2006.01) (86) International application number: PCT/US2009/040813 (87) International publication number: WO 2009/137254 (12.11.2009 Gazette 2009/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 16.04.2008 US 124567 P 17.04.2008 US 45961 P (71) Applicants: Bayer HealthCare LLC Tarrytown, NY 10591 (US) Bayer Schering Pharma Aktiengesellschaft 13353 Berlin (DE)

(72) Inventors: BROOKS, Alan Clayton, CA 94517 (US) MURPHY, John, E. Berkeley, CA 94707 (US) SETO, Marian Orinda, CA 94563 (US) JIANG, Xiaoqiao Concord, CA 94518 (US) PATEL, Chandra Foster City, CA 94404 (US) GRITZAN, Uwe 50823 Köln (DE) KIRCHNER, Kornelia 50226 Frechen (DE) HAUPTS, Ulrich 51519 Odenthal (DE) (74) Representative: Burkert, Frank  Bayer HealthCare AG LP-PL, Q18 51368 Leverkusen 51368 Leverkusen (DE)