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EP 2 291 351 A1

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(43) Date of publication: 09.03.2011 Bulletin 2011/10 (21) Application number: 08750117.7 (22) Date of filing: 07.05.2008

(51) International Patent Classification (IPC):  C07C 323/60(2006.01) C07D 241/20(2006.01) C07D 277/64(2006.01) A61K 31/16(2006.01) A61K 31/415(2006.01) A61K 31/428(2006.01) A61K 31/53(2006.01) A61P 3/10(2006.01) C07D 231/40(2006.01) C07D 263/56(2006.01) C07D 285/135(2006.01) A61K 31/165(2006.01) A61K 31/423(2006.01) A61K 31/433(2006.01) A61P 3/04(2006.01) (86) International application number: PCT/EP2008/055594 (87) International publication number: WO 2009/135526 (12.11.2009 Gazette 2009/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (71) Applicant: Novartis AG 4056 Basel (CH)	(72) Inventors: NAPOLETANO, Mauro I-20127 Milano (IT) HAACK, Thomas I-22100 Como (IT) TSCHINKE, Vincenzo CH-4102 Binningen (CH) JELAKOVIC, Stjepan 79100 Freiburg (DE) MAH, Robert CH-4132 Muttenz (CH) (74) Representative: von Sprecher, Georg et al Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)