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EP 2 291 369 A1

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(43) Date of publication: 09.03.2011 Bulletin 2011/10 (21) Application number: 09750866.7 (22) Date of filing: 20.05.2009

(51) International Patent Classification (IPC):  C07D 409/14(2006.01) A61K 31/4439(2006.01) A61P 29/00(2006.01) C07D 407/14(2006.01) A61K 31/416(2006.01) A61P 11/00(2006.01) C07D 407/12(2006.01) (86) International application number: PCT/SE2009/000267 (87) International publication number: WO 2009/142571 (26.11.2009 Gazette 2009/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 20.05.2008 US 54616 14.07.2008 US 80312 15.01.2009 US 144776 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)

(72) Inventors: BAYER SCHERING PHARMA AG D-13353 Berlin (DE) BERGER, Markus D-13353 Berlin (DE) DAHMEN, Jan S-221 87 Lund (SE) EDMAN, Karl S-431 83 Mölndal (SE) ERIKSSON, Anders S-221 87 Lund (SE) HANSSON, Thomas S-221 87 Lund (SE) HEMMERLING, Martin S-221 87 Lund (DE) HOSSAIN Nafizal S-221 87 Lund (SE) KLINGSTEDT, Tomas S-221 87 Lund (SE) LEPISTÖ, Matti S-221 87 Lund (SE) NILSSON, Stinabritt S-221 87 Lund (SE) REHWINKEL, Hartmut D-13353 Berlin (DE)