(19)

(11)

EP 2 291 405 A1

(12)

(43) Date of publication: 09.03.2011 Bulletin 2011/10 (21) Application number: 09747445.6 (22) Date of filing: 13.05.2009

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 25/28(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2009/043757 (87) International publication number: WO 2009/140361 (19.11.2009 Gazette 2009/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 09.12.2008 US 316130 13.05.2008 US 52949 P 11.09.2008 US 208883 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: ATAWAL, Jasvinder San Carlos, CA 94070 (US) TESSIER-LAVIGNE, Marc Woodside, CA 94062 (US) WU, Yan Foster City, CA 94404 (US) (74) Representative: Walton, Seán Malcolm  Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)