(19)

(11)

EP 2 291 663 A2

(12)

(88) Date of publication A3: 11.03.2010 (43) Date of publication: 09.03.2011 Bulletin 2011/10 (21) Application number: 09763473.7 (22) Date of filing: 09.06.2009

(51) International Patent Classification (IPC):  G01N 35/02(2006.01) G01N 33/50(2006.01) (86) International application number: PCT/US2009/046795 (87) International publication number: WO 2009/152183 (17.12.2009 Gazette 2009/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 09.09.2008 US 207343 09.06.2008 US 60070 P 06.02.2009 US 150599 P (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: ADEY, Nils Salt Lake City UT 84108 (US) MOYER, Tom Salt Lake City UT 84124 (US) PARRY, Rob Park City UT 84098 (US) EMERY, Dale Salt Lake City UT 84109 (US) (74) Representative: Bösl, Raphael Konrad  Isenbruck Bösl Hörschler LLP Patentanwälte Prinzregentenstrasse 68 81675 München 81675 München (DE)